A competitive advantage through fast dead matter elimination in confined cellular aggregates
نویسندگان
چکیده
Abstract Competition of different species or cell types for limited space is relevant in a variety biological processes such as biofilm development, tissue morphogenesis and tumor growth. Predicting the outcome non-adversarial competition growing active matter non-trivial, it depends on how like growth, proliferation degradation cellular are regulated confinement; regulation that happens even absence to achieve dynamic steady state known homeostasis. Here, we show passive by-products maintaining homeostasis can significantly alter fitness. Even purely pressure-regulated growth exclusively mechanical interactions, this enables with lower homeostatic pressure outcompete those higher pressure. We reveal interfaces play critical role specific kind competition: there, proportion cells better exploit local opportunities continuously arise keep system out equilibrium. elucidate effect theoretical toy model test an agent-based computational includes finite-time persistence dead thereby decouples density from Our results suggest self-organization aggregates into be decisive outcomes optimizing (active) important survival sensitivity cues.
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ژورنال
عنوان ژورنال: New Journal of Physics
سال: 2022
ISSN: ['1367-2630']
DOI: https://doi.org/10.1088/1367-2630/ac788e